InaD-like protein

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

InaD-like protein is a protein that in humans is encoded by the PATJ gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesPATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
Quick facts PATJ, Available structures ...
PATJ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
External IDsOMIM: 603199; MGI: 1277960; HomoloGene: 72199; GeneCards: PATJ; OMA:PATJ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005799
NM_176877
NM_176878
NM_001350145

NM_001005784
NM_001005787
NM_007704
NM_172696
NM_001355177

RefSeq (protein)

NP_795352
NP_001337074

NP_001005784
NP_001005787
NP_031730
NP_766284
NP_001342106

Location (UCSC)Chr 1: 61.74 – 62.18 MbChr 4: 98.28 – 98.61 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[7]

Interactions

INADL has been shown to interact with MPP5.[8]

References

Further reading

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