ITK (gene)
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene.[5] ITK is a member of the TEC family of kinases and is highly expressed in T cells.[6]
Function
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein is thought to play a role in T-cell proliferation and differentiation.[7][8] ITK is functionally important for the development and effector function of Th2 and Th17 cells.[6]
Mice lacking ITK were shown to not be susceptible to asthma.[9]
Structure
This protein contains the following domains, which are often found in intracellular kinases:[10]
- N-terminus – PH (pleckstrin homology domain)
- TH – Tec family homology domain (including Bruton's tyrosine kinase Cys-rich motif and Proline rich region)
- SH3 – (Src homology 3)
- SH2 – (Src homology 2)
- C-terminus – tyrosine kinase, catalytic domain
Interactions
Inhibitors
- Soquelitinib (CPI-818)
