L-759,633

L-759,633 is an analgesic drug that is a cannabinoid agonist. It is a fairly selective agonist for the CB₂ receptor, with selectivity of 163x for CB₂ over CB₁.^[1]

CAS Number

• 174627-50-0 ^N

PubChem CID

• 5311215

IUPHAR/BPS

• 748

ChemSpider

• 4470734 ^N

Quick facts Identifiers, CAS Number ...

L-759,633

Identifiers
IUPAC name (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene
CAS Number	174627-50-0 N
PubChem CID	5311215
IUPHAR/BPS	748
ChemSpider	4470734 N
ChEBI	CHEBI:191050
ChEMBL	ChEMBL57367 N
Chemical and physical data
Formula	C26H40O2
Molar mass	384.604 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCC(C)(C)c1cc2c(c(c1)OC)[C@@H]3CC(=CC[C@H]3C(O2)(C)C)C
InChI InChI=1S/C26H40O2/c1-8-9-10-11-14-25(3,4)19-16-22(27-7)24-20-15-18(2)12-13-21(20)26(5,6)28-23(24)17-19/h12,16-17,20-21H,8-11,13-15H2,1-7H3/t20-,21-/m1/s1 N Key:SUFMHSFGODDLKI-NHCUHLMSSA-N N
NY (what is this?)  (verify)

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It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂.^[2][3]