PCNA-associated factor

PCLAF
Identifiers
Aliases	PCLAF, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDs	OMIM: 610696; MGI: 1915276; GeneCards: PCLAF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D2G
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,387,687 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,810,548 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; embryo; ; ventricular zone; ; ganglionic eminence; ; bone marrow; ; gingival epithelium; ; thymus; ; hair follicle; ; bone marrow cell; ; oral cavity;
	Top expressed in
	yolk sac; ; tail of embryo; ; somite; ; embryo; ; ventricular zone; ; genital tubercle; ; embryo; ; maxillary prominence; ; mandibular prominence; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; nucleus; nucleoplasm; cytoplasm; centrosome;
Biological process	DNA replication; translesion synthesis; response to UV; cellular response to DNA damage stimulus; regulation of cell cycle; DNA repair; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9768
	68026
	ENSG00000166803
	ENSMUSG00000040204
	Q15004
	Q9CQX4
	NM_001029989; NM_014736
	NM_026515
	NP_001025160; NP_055551
	NP_080791
	Wikidata
View/Edit Human	View/Edit Mouse

PCNA-associated factor (also called “PCNA clamp associated factor”) is a protein that in humans is encoded by the PCLAF gene (previously KIAA0101).^[5]^[6]^[7] The PCLAF protein binds to PCNA and regulates DNA repair during DNA replication.^[8]