Importin subunit alpha-7

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesKPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6

External IDsOMIM: 610563; MGI: 1100836; HomoloGene: 22472; GeneCards: KPNA6; OMA:KPNA6 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts KPNA6, Available structures ...

KPNA6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UAD
Identifiers
Aliases	KPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6
External IDs	OMIM: 610563; MGI: 1100836; HomoloGene: 22472; GeneCards: KPNA6; OMA:KPNA6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 32,108,056 bp[1] End 32,176,563 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,537,773 bp[2] End 129,566,560 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell nipple oocyte olfactory bulb beta cell secondary oocyte vena cava saphenous vein Skeletal muscle tissue of rectus abdominis superior surface of tongue Top expressed in spermatid spermatocyte cumulus cell saccule otic placode seminiferous tubule substantia nigra retinal pigment epithelium Epithelium of choroid plexus Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore membrane nucleus nucleoplasm host cell Biological process protein transport maternal process involved in female pregnancy positive regulation of transcription by RNA polymerase II protein import into nucleus NLS-bearing protein import into nucleus transport entry of viral genome into host nucleus through nuclear pore complex via importin positive regulation of cytokine production involved in inflammatory response positive regulation of viral life cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23633 16650 Ensembl ENSG00000025800 ENSMUSG00000003731 UniProt O60684 O35345 RefSeq (mRNA) NM_012316 NM_008468 RefSeq (protein) NP_036448 NP_032494 Location (UCSC) Chr 1: 32.11 – 32.18 Mb Chr 4: 129.54 – 129.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.^[6]