Keratin 10

Protein found in humans From Wikipedia, the free encyclopedia

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.[5][6][7] Keratin 10 is a type I keratin.

PDBOrtholog search: PDBe RCSB
AliasesKRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
Quick facts KRT10, Available structures ...
KRT10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDsOMIM: 148080; MGI: 96685; GeneCards: KRT10; OMA:KRT10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000421
NM_001379366

NM_010660

RefSeq (protein)

NP_000412
NP_001366295

NP_034790

Location (UCSC)Chr 17: 40.82 – 40.82 MbChr 11: 99.28 – 99.28 Mb
PubMed search[3][4]
Wikidata
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Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.[7]

Interactions

Keratin 10 has been shown to interact with AKT1.[8]

See also

References

Further reading

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