Keratin 12

Keratin 12 is a protein that in humans is encoded by the KRT12 gene.^[5][6] It is a type I keratin.

AliasesKRT12, K12, keratin 12, MECD1

External IDsOMIM: 601687; MGI: 96687; HomoloGene: 188; GeneCards: KRT12; OMA:KRT12 - orthologs

Chr.Chromosome 17 (human)^[1]

End40,867,223 bp^[1]

Quick facts KRT12, Identifiers ...

KRT12
Identifiers
Aliases	KRT12, K12, keratin 12, MECD1
External IDs	OMIM: 601687; MGI: 96687; HomoloGene: 188; GeneCards: KRT12; OMA:KRT12 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,861,303 bp[1] End 40,867,223 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 62.92 cM Start 99,306,492 bp[2] End 99,313,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle mucosa of transverse colon eye duodenum skin of abdomen rectum skin of leg vagina ectocervix Top expressed in corneal stroma ciliary body conjunctival fornix epithelium of lens retinal pigment epithelium primary oocyte olfactory tubercle piriform cortex secondary oocyte iris More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament extracellular exosome cytosol Biological process visual perception keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3859 268482 Ensembl ENSG00000187242 ENSMUSG00000020912 UniProt Q99456 Q64291 RefSeq (mRNA) NM_000223 NM_010661 RefSeq (protein) NP_000214 NP_034791 Location (UCSC) Chr 17: 40.86 – 40.87 Mb Chr 11: 99.31 – 99.31 Mb PubMed search [3] [4]
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Keratin 12 is keratin found expressed in corneal epithelia. Mutations in the gene encoding this protein lead to Meesmann corneal dystrophy.^[5]