Keratin 13

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.^[5][6]

AliasesKRT13, CK13, K13, WSN2, keratin 13

External IDsOMIM: 148065; MGI: 101925; HomoloGene: 40740; GeneCards: KRT13; OMA:KRT13 - orthologs

Chr.Chromosome 17 (human)^[1]

End41,505,705 bp^[1]

Quick facts KRT13, Identifiers ...

KRT13
Identifiers
Aliases	KRT13, CK13, K13, WSN2, keratin 13
External IDs	OMIM: 148065; MGI: 101925; HomoloGene: 40740; GeneCards: KRT13; OMA:KRT13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,500,981 bp[1] End 41,505,705 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.41 cM Start 100,008,153 bp[2] End 100,012,392 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx oral cavity gums gingival epithelium body of tongue buccal mucosa cell palpebral conjunctiva vulva superior surface of tongue cervix epithelium Top expressed in superior surface of tongue esophagus corneal stroma molar conjunctival fornix umbilical cord lip cervix oral mucosa middle ear More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity protein binding Cellular component intermediate filament cytoskeleton keratin filament extracellular exosome intermediate filament nucleus cytosol Biological process cellular response to retinoic acid response to radiation cytoskeleton organization tongue morphogenesis keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3860 16663 Ensembl ENSG00000171401 ENSMUSG00000044041 UniProt P13646 P08730 RefSeq (mRNA) NM_153490 NM_002274 NM_010662 NM_001313949 RefSeq (protein) NP_002265 NP_705694 NP_001300878 NP_034792 Location (UCSC) Chr 17: 41.5 – 41.51 Mb Chr 11: 100.01 – 100.01 Mb PubMed search [3] [4]
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Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.^[7]