Keratin 17

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.^[5][6][7][8]

AliasesKRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17

External IDsOMIM: 148069; MGI: 96691; HomoloGene: 363; GeneCards: KRT17; OMA:KRT17 - orthologs

Chr.Chromosome 17 (human)^[1]

End41,624,842 bp^[1]

Quick facts KRT17, Identifiers ...

KRT17
Identifiers
Aliases	KRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17
External IDs	OMIM: 148069; MGI: 96691; HomoloGene: 363; GeneCards: KRT17; OMA:KRT17 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,619,442 bp[1] End 41,624,842 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.44 cM Start 100,147,043 bp[2] End 100,151,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium olfactory zone of nasal mucosa amniotic fluid vulva skin of thigh hair follicle skin of arm skin of abdomen nipple buccal mucosa cell Top expressed in lip molar skin of back epidermis hair follicle skin of external ear skin of abdomen thymus corneal stroma hair More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton MHC class II receptor activity protein binding structural molecule activity MHC class II protein binding Cellular component cytoplasm extracellular exosome intermediate filament cell periphery cytosol intermediate filament cytoskeleton Biological process morphogenesis of an epithelium positive regulation of hair follicle development hair follicle morphogenesis intermediate filament organization positive regulation of cell growth positive regulation of translation signal transduction epidermis development keratinization cornification cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3872 16667 Ensembl ENSG00000128422 ENSMUSG00000035557 UniProt Q04695 Q9QWL7 RefSeq (mRNA) NM_000422 NM_010663 RefSeq (protein) NP_000413 NP_034793 Location (UCSC) Chr 17: 41.62 – 41.62 Mb Chr 11: 100.15 – 100.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.^[8]