KduI/IolB isomerase family
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| KduI/IolB family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of 4-deoxy-1-threo-5-hexosulose-uronate ketol-isomerase from enterococcus faecalis | |||||||||
| Identifiers | |||||||||
| Symbol | KduI | ||||||||
| Pfam | PF04962 | ||||||||
| Pfam clan | CL0029 | ||||||||
| InterPro | IPR021120 | ||||||||
| |||||||||
In molecular biology, the KduI/IolB isomerase family is a family of isomerase enzymes that includes 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (5-keto 4-deoxyuronate isomerase) (KduI) and 5-deoxy-glucuronate isomerase (5DG isomerase) (IolB).
KduI is involved in pectin degradation by free-living soil bacteria that use pectin as a carbon source, breaking it down to 2-keto-3-deoxygluconate, which can ultimately be converted to pyruvate. KduI catalyses the fourth step in pectin degradation, namely the interconversion of 5-keto-4-deoxyuronate and 2,5-diketo-3-dexoygluconate.[1] KduI has a TIM-barrel fold.[2]
This family also includes several bacterial Myo-inositol catabolism proteins, such as IolB, which is encoded by the inositol operon (iolABCDEFGHIJ) in Bacillus subtilis. IolB is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR.[3] Members of this family possess a Cupin like structure.