De Cuyper, the youngest brother of three sculptors, was born in Antwerp on 1 January 1813.[3] He was a student of his brother Jean-Baptiste De Cuyper.[4] He continued his studies at the Academy in Antwerp.[4] He was a sculptor at the Russian Court for some time.[4] Back in Belgium, he had the Cuypershof residence with a detached studio built in Klein-Antwerpen (the house was demolished in 1928 and replaced by a new building. Today Résidence Isabelle stands there).[4] In 1854 the Kunstverbond was founded under Cuypers' leadership, which was later also called the Nederlandsch Kunstverbond to distinguish it from the French-speaking Cercle Artistique.