Late endosomal/lysosomal adaptor, mapk and mtor activator 1

LAMTOR1
Identifiers
Aliases	LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
External IDs	OMIM: 613510; MGI: 1913758; HomoloGene: 9909; GeneCards: LAMTOR1; OMA:LAMTOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,103,297 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,575,882 bp
RNA expression pattern
	Top expressed in
	monocyte; ; mucosa of ileum; ; granulocyte; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; C1 segment; ; left lobe of thyroid gland;
	Top expressed in
	white adipose tissue; ; quadriceps femoris muscle; ; yolk sac; ; lip; ; granulocyte; ; skeletal muscle tissue; ; proximal tubule; ; right kidney; ; muscle of thigh; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; protein binding; molecular adaptor activity; GTPase binding;
Cellular component	endosome; late endosome membrane; membrane; Ragulator complex; lysosomal membrane; membrane raft; lysosome; extracellular exosome; plasma membrane; azurophil granule membrane; specific granule membrane; ficolin-1-rich granule membrane;
Biological process	regulation of cholesterol import; regulation of cholesterol efflux; endosome organization; lysosome localization; cellular response to amino acid stimulus; cholesterol homeostasis; regulation of receptor recycling; lysosome organization; regulation of cholesterol esterification; positive regulation of TOR signaling; positive regulation of MAPK cascade; neutrophil degranulation; regulation of macroautophagy; regulation of cell growth; regulation of molecular function; endosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	55004
	66508
	ENSG00000149357
	ENSMUSG00000030842
	Q6IAA8
	Q9CQ22
	NM_017907
	NM_025605
	NP_060377
	NP_079881
	Wikidata
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