Lactate dehydrogenase A

Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD⁺. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.^[6]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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Glycolysis and Gluconeogenesis edit

1. [1]

   The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

The following compounds have been demonstrated to inhibit the LDHA enzyme:

• Oxamate^[7]
• Epigallocatechin gallate^[8]
• Quinoline 3-sulfonamide^[9]
• CHK-336^[10]