LY-293284

LY-293284
Clinical data
Other names	LY293284; 4,α-Methylene-5-acetyl-N,N-dipropyltryptamine; 4,α-Methylene-5-acetyl-DPT
Drug class	Serotonin 5-HT1A receptor agonist; Simplified/partial LSD analogue
Identifiers
	IUPAC name (4R)-6-acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz[c,d]indole;
CAS Number	141318-62-9 ;
PubChem CID	132345;
IUPHAR/BPS	19;
ChemSpider	116875;
UNII	92MME29XHM;
CompTox Dashboard (EPA)	DTXSID70161692 ;
Chemical and physical data
Formula	C19H26N2O
Molar mass	298.430 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CCC)[C@H]1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1;
	InChI InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3/t15-/m0/s1; Key:CKYZLYQSDNLGPT-HNNXBMFYSA-N;
	(verify)

LY-293284, also known as 4,α-methylene-5-acetyl-DPT, is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT_1A receptor full agonist (K_i = 0.088 nM; EC₅₀Tooltip half-maximal effective concentration = 0.13 nM).^[1] It was derived through structural simplification of the ergoline based psychedelic LSD,^[2] but is far more selective for 5-HT_1A with over 1,000-fold selectivity over other serotonin receptor subtypes and other targets.^[3] It has anxiogenic effects in animal studies.^[4] In addition, it does not substitute for LSD in rodent drug discrimination tests.^[1]