MINK1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.[5][6][7]

AliasesMINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
End4,898,061 bp[1]
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MINK1
Identifiers
AliasesMINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
External IDsOMIM: 609426; MGI: 1355329; HomoloGene: 56762; GeneCards: MINK1; OMA:MINK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024937
NM_015716
NM_153827
NM_170663
NM_001321236

NM_001045959
NM_001045964
NM_016713
NM_176893

RefSeq (protein)

NP_001020108
NP_001308165
NP_056531
NP_722549
NP_733763

Location (UCSC)Chr 17: 4.83 – 4.9 MbChr 11: 70.45 – 70.51 Mb
PubMed search[3][4]
Wikidata
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Function

Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.[7]

Interactions

MINK1 has been shown to interact with NCK1.[8]

References

Further reading

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