Afadin

AFDN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T2M, 1XZ9, 2AIN, 2EXG, 5A6C
Identifiers
Aliases	AFDN, AF6, MLL-AF6, MLLT4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4, afadin, adherens junction formation factor, l-afadin
External IDs	OMIM: 159559; MGI: 1314653; HomoloGene: 21202; GeneCards: AFDN; OMA:AFDN - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	167,972,023 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	14,126,412 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; bronchial epithelial cell; ; ganglionic eminence; ; right lung; ; buccal mucosa cell; ; minor salivary glands; ; body of pancreas; ; rectum; ; caput epididymis;
	Top expressed in
	lip; ; superior cervical ganglion; ; hair follicle; ; skin of abdomen; ; skin of external ear; ; gastrula; ; otolith organ; ; utricle; ; conjunctival fornix; ; medullary collecting duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; protein binding; cadherin binding; cell adhesion molecule binding; actin filament binding;
Cellular component	adherens junction; cell junction; plasma membrane; nucleoplasm; cytosol; cell-cell junction; nuclear speck; cell-cell contact zone; tight junctions;
Biological process	cell-cell signaling; positive regulation of GTPase activity; cell adhesion; establishment of endothelial intestinal barrier; signal transduction; regulation of protein localization; adherens junction organization; positive regulation of gene expression; positive regulation of cell-cell adhesion; negative regulation of cell migration; cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; bicellular tight junction assembly; positive regulation of cell-cell adhesion mediated by cadherin;
	Sources:Amigo / QuickGO
Orthologs
	4301
	17356
	ENSG00000130396
	ENSMUSG00000068036
	P55196
	Q9QZQ1
NM_001040000; NM_001040001; NM_001207008; NM_001291964; NM_005936;
	NM_001366319; NM_001366320; NM_001366321; NM_001386888
	NM_010806
NP_001035089; NP_001193937; NP_001278893; NP_001353248; NP_001353249;
	NP_001353250
	NP_034936
	Wikidata
View/Edit Human	View/Edit Mouse

Afadin is a protein that in humans is encoded by the AFDN gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesAFDN, AF6, MLL-AF6, MLLT4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4, afadin, adherens junction formation factor, l-afadin

External IDsOMIM: 159559; MGI: 1314653; HomoloGene: 21202; GeneCards: AFDN; OMA:AFDN - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts AFDN, Available structures ...

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[5]

[1]

[2]

[3]

[4]

Afadin

Function

Interactions

References

Further reading

Related Articles

Related Articles

"The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain"

"PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor"

"The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin"

"Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein"

"Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions"

"The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme"

"Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction"

"Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions"