Mitochondrial ribosomal protein L12

39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.^[4][5][6]

AliasesMRPL12, 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, mitochondrial ribosomal protein L12

External IDsOMIM: 602375; MGI: 1926273; HomoloGene: 2212; GeneCards: MRPL12; OMA:MRPL12 - orthologs

Chr.Chromosome 17 (human)^[1]

End81,707,517 bp^[1]

Quick facts MRPL12, Identifiers ...

MRPL12
Identifiers
Aliases	MRPL12, 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, mitochondrial ribosomal protein L12
External IDs	OMIM: 602375; MGI: 1926273; HomoloGene: 2212; GeneCards: MRPL12; OMA:MRPL12 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,703,367 bp[1] End 81,707,517 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon left ventricle right auricle of heart muscle of thigh right lobe of liver gastrocnemius muscle mucosa of esophagus human kidney skeletal muscle tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrial large ribosomal subunit mitochondrion Biological process positive regulation of transcription, DNA-templated mitochondrial transcription mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6182 56282 Ensembl ENSG00000262814 ENSMUSG00000039640 UniProt P52815 Q9DB15 RefSeq (mRNA) NM_002949 NM_027204 RefSeq (protein) NP_002940 NP_081480 Location (UCSC) Chr 17: 81.7 – 81.71 Mb n/a PubMed search [2] [3]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.^[6]