Mitochondrial ribosomal protein L15

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMRPL15, L15mt, MRP-L15, MRP-L7, RPML7, HSPC145, mitochondrial ribosomal protein L15

External IDsOMIM: 611828; MGI: 1351639; HomoloGene: 32210; GeneCards: MRPL15; OMA:MRPL15 - orthologs

Chr.Chromosome 8 (human)^[1]

Quick facts MRPL15, Available structures ...

MRPL15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL15, L15mt, MRP-L15, MRP-L7, RPML7, HSPC145, mitochondrial ribosomal protein L15
External IDs	OMIM: 611828; MGI: 1351639; HomoloGene: 32210; GeneCards: MRPL15; OMA:MRPL15 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.23 Start 54,135,241 bp[1] End 54,148,514 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A1 Start 4,843,429 bp[2] End 4,855,962 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle vastus lateralis muscle biceps brachii muscle of thigh gastrocnemius muscle Skeletal muscle tissue of biceps brachii deltoid muscle triceps brachii muscle left ventricle gonad Top expressed in morula sternocleidomastoid muscle embryo digastric muscle muscle of thigh temporal muscle epiblast extraocular muscle embryo blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane large ribosomal subunit ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29088 27395 Ensembl ENSG00000137547 ENSMUSG00000033845 UniProt Q9P015 Q9CPR5 RefSeq (mRNA) NM_014175 NM_001177658 NM_025300 RefSeq (protein) NP_054894 NP_001171129 NP_079576 Location (UCSC) Chr 8: 54.14 – 54.15 Mb Chr 1: 4.84 – 4.86 Mb PubMed search [3] [4]
Wikidata
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.^[6]