Mitochondrial ribosomal protein L17

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesMRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17

External IDsOMIM: 611830; MGI: 1351608; HomoloGene: 32526; GeneCards: MRPL17; OMA:MRPL17 - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts MRPL17, Available structures ...

MRPL17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQM, 3J7Y, 3J9M
Identifiers
Aliases	MRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDs	OMIM: 611830; MGI: 1351608; HomoloGene: 32526; GeneCards: MRPL17; OMA:MRPL17 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,680,385 bp[1] End 6,683,340 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,452,413 bp[2] End 105,460,306 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium apex of heart anterior pituitary left adrenal gland right ventricle right adrenal gland left adrenal cortex gonad right adrenal cortex muscle of thigh Top expressed in blastocyst embryo embryo yolk sac morula right kidney otic placode lip muscle of thigh epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein domain specific binding Cellular component ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit mitochondrial inner membrane Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial genome maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63875 27397 Ensembl ENSG00000158042 ENSMUSG00000030879 UniProt Q9NRX2 Q9D8P4 RefSeq (mRNA) NM_022061 NM_025301 RefSeq (protein) NP_071344 NP_079577 Location (UCSC) Chr 11: 6.68 – 6.68 Mb Chr 7: 105.45 – 105.46 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[5]