Mitochondrial ribosomal protein L19

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.^[5][6][7]

AliasesMRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19

External IDsOMIM: 611832; MGI: 1926274; GeneCards: MRPL19

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts MRPL19, Identifiers ...

MRPL19
Identifiers
Aliases	MRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832; MGI: 1926274; GeneCards: MRPL19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 75,646,783 bp[1] End 75,690,851 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.81 cM Start 81,934,832 bp[2] End 81,942,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right adrenal gland Skeletal muscle tissue of biceps brachii left adrenal gland rectum right adrenal cortex gingival epithelium left adrenal cortex islet of Langerhans muscle of thigh Top expressed in endocardial cushion medullary collecting duct epiblast otic placode migratory enteric neural crest cell blastocyst atrioventricular valve atrium renal corpuscle lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome nuclear membrane intracellular anatomical structure nucleus mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9801 56284 Ensembl ENSG00000115364 ENSMUSG00000030045 UniProt P49406 Q9D338 RefSeq (mRNA) NM_014763 NM_026490 RefSeq (protein) NP_055578 NP_080766 Location (UCSC) Chr 2: 75.65 – 75.69 Mb Chr 6: 81.93 – 81.94 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[7]