Mitochondrial ribosomal protein L20

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesMRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20

External IDsOMIM: 611833; MGI: 2137221; HomoloGene: 9941; GeneCards: MRPL20; OMA:MRPL20 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts MRPL20, Available structures ...

MRPL20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDs	OMIM: 611833; MGI: 2137221; HomoloGene: 9941; GeneCards: MRPL20; OMA:MRPL20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,401,909 bp[1] End 1,407,293 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 87.44 cM Start 155,887,335 bp[2] End 155,894,432 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of nasopharynx germinal epithelium gingival epithelium Skeletal muscle tissue of rectus abdominis muscle of thigh amniotic fluid corpus epididymis mucosa of paranasal sinus Skeletal muscle tissue of biceps brachii Top expressed in gastrula right kidney embryo embryo spermatocyte spermatid morula epiblast submandibular gland neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding protein binding RNA binding structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis ribosomal large subunit assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55052 66448 Ensembl ENSG00000242485 ENSMUSG00000029066 UniProt Q9BYC9 Q9CQL4 RefSeq (mRNA) NM_017971 NM_001318485 NM_025570 RefSeq (protein) NP_001305414 NP_060441 NP_079846 Location (UCSC) Chr 1: 1.4 – 1.41 Mb Chr 4: 155.89 – 155.89 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.^[5]