Mitochondrial ribosomal protein S28

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesMRPS28, MRP-S28, MRP-S35, MRPS35, HSPC007, mitochondrial ribosomal protein S28, COXPD47

External IDsOMIM: 611990; MGI: 1913480; HomoloGene: 8519; GeneCards: MRPS28; OMA:MRPS28 - orthologs

Chr.Chromosome 8 (human)^[1]

Quick facts MRPS28, Available structures ...

MRPS28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS28, MRP-S28, MRP-S35, MRPS35, HSPC007, mitochondrial ribosomal protein S28, COXPD47
External IDs	OMIM: 611990; MGI: 1913480; HomoloGene: 8519; GeneCards: MRPS28; OMA:MRPS28 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 79,918,717 bp[1] End 80,030,289 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 8,867,206 bp[2] End 8,988,978 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland muscle of thigh left adrenal cortex gastrocnemius muscle islet of Langerhans left ventricle substantia nigra skeletal muscle tissue Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle soleus muscle skeletal muscle tissue extraocular muscle quadriceps femoris muscle tibialis anterior muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28957 66230 Ensembl ENSG00000147586 ENSMUSG00000040269 UniProt Q9Y2Q9 Q9CY16 RefSeq (mRNA) NM_014018 NM_025434 RefSeq (protein) NP_054737 NP_079710 Location (UCSC) Chr 8: 79.92 – 80.03 Mb Chr 3: 8.87 – 8.99 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature.^[7]