Mitochondrial ribosomal protein S30

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesMRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30

External IDsOMIM: 611991; MGI: 1926237; HomoloGene: 9607; GeneCards: MRPS30; OMA:MRPS30 - orthologs

Chr.Chromosome 5 (human)^[1]

Quick facts MRPS30, Available structures ...

MRPS30
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30
External IDs	OMIM: 611991; MGI: 1926237; HomoloGene: 9607; GeneCards: MRPS30; OMA:MRPS30 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p12 Start 44,808,947 bp[1] End 44,820,428 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.3 Start 118,514,917 bp[2] End 118,523,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell gonad Brodmann area 23 middle temporal gyrus muscle of thigh gastrocnemius muscle ganglionic eminence rectum ventricular zone biceps brachii Top expressed in interventricular septum endocardial cushion cumulus cell soleus muscle atrioventricular valve somite brown adipose tissue mandibular prominence migratory enteric neural crest cell abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10884 59054 Ensembl ENSG00000112996 ENSMUSG00000021731 UniProt Q9NP92 Q9D0G0 RefSeq (mRNA) NM_016640 NM_021556 RefSeq (protein) NP_057724 NP_067531 Location (UCSC) Chr 5: 44.81 – 44.82 Mb Chr 13: 118.51 – 118.52 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.^[7]