Mitochondrial ribosomal protein S6

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesMRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6

External IDsOMIM: 611973; MGI: 2153111; HomoloGene: 41871; GeneCards: MRPS6; OMA:MRPS6 - orthologs

Chr.Chromosome 21 (human)^[1]

Quick facts MRPS6, Available structures ...

MRPS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDs	OMIM: 611973; MGI: 2153111; HomoloGene: 41871; GeneCards: MRPS6; OMA:MRPS6 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 34,073,224 bp[1] End 34,143,034 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 91,855,158 bp[2] End 91,909,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla left lobe of thyroid gland decidua gonad human kidney right lobe of thyroid gland tibial arteries right adrenal cortex right coronary artery tibial nerve Top expressed in vestibular membrane of cochlear duct Epithelium of choroid plexus vestibular sensory epithelium retinal pigment epithelium epithelium of lens endothelial cell of lymphatic vessel ciliary body right kidney medullary collecting duct sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome rRNA binding protein binding small ribosomal subunit rRNA binding Cellular component small ribosomal subunit mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64968 121022 Ensembl ENSG00000243927 ENSMUSG00000039680 UniProt P82932 P58064 RefSeq (mRNA) NM_032476 NM_080456 RefSeq (protein) NP_115865 NP_536704 Location (UCSC) Chr 21: 34.07 – 34.14 Mb Chr 16: 91.86 – 91.91 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.^[5]