miR398 microRNA precursor family
RNA family
From Wikipedia, the free encyclopedia
In molecular biology, miR398 is a conserved microRNA found in plants that regulates genes involved in copper homeostasis and oxidative stress responses.[1][2] Like other plant microRNAs, miR398 regulates gene expression primarily through sequence-directed cleavage of target mRNAs.
| miR398 | |
|---|---|
| Identifiers | |
| Symbol | miR398 |
| Rfam | RF00695 |
| miRBase family | MIPF0000107 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| PDB structures | PDBe |
In Arabidopsis thaliana, miR398 targets transcripts encoding the copper/zinc superoxide dismutases CSD1 and CSD2, as well as the copper chaperone for superoxide dismutase (CCS).[1][3] Expression of miR398 is dynamically regulated by environmental conditions, including oxidative stress, sucrose signaling, and copper availability.[4][5]
Under copper deficiency, transcription factors such as SPL7 coordinate the induction of miR398 and related regulatory pathways to prioritize copper allocation to essential proteins.[2] Through this regulatory network, miR398 contributes to plant adaptation to oxidative and nutrient stress conditions.
