Mitoquinone mesylate

Mitoquinone mesylate (MitoQ) is a synthetic analogue of coenzyme Q10 which has antioxidant effects. It was first developed in New Zealand in the late 1990s.^[1] It has significantly improved bioavailability and improved mitochondrial penetration compared to coenzyme Q10,^[2][3] and has shown potential in a number of medical indications,^[4][5][6][7] being widely sold as a dietary supplement.^[8][9]

Trade namesMitoQ

CAS Number

• 845959-50-4

PubChem CID

• 11388331

ChemSpider

• 9563239

Quick facts Clinical data, Trade names ...

Mitoquinone mesylate

Clinical data
Trade names	MitoQ
Identifiers
IUPAC name 10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium methanesulfonate
CAS Number	845959-50-4
PubChem CID	11388331
ChemSpider	9563239
UNII	6E01CG547T
ChEMBL	ChEMBL4074884
CompTox Dashboard (EPA)	DTXSID00233573
Chemical and physical data
Formula	C38H47O7PS
Molar mass	678.82 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)[O-]
InChI InChI=1S/C37H44O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32;1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1 Key:GVZFUVXPTPGOQT-UHFFFAOYSA-M

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A 2014 review found insufficient evidence for the use of mitoquinone mesylate in Parkinson's disease and other movement disorders.^[10]

A 2025 British study found that diabetes patients who took daily mitoquinone, a widely available antioxidant, as well as their standard treatment had healthier hearts after four months than those not given the supplement. Mitoquinone was able to reverse the early signs of diabetes-related heart failure over the course of the study.^[11]