My Little Juan

• Tetchie Agbayani as Doña Tomasa Calibaquib / Evelyn Bunag

- Doña Tomasa was a stereotypical corrupt woman. She made many schemes to acquire more riches, even it means swindling the townspeople of San Juan Bautista. She valued material wealth highly. When flashfloods entered her residence, she was quick to order her helpers to saver her antique vases and paintings from the floods. Tomasa has a dark past was bullied during her childhood and this caused her hunger for approval. This caused her to seek for a town award, believing it would satisfy her need for approval. She even bribed the judges just to get the award.

• Smokey Manaloto as Alvin Balmaceda

- Alvin is a steady presence for his wife, Ruth. However, beneath his calm exterior is a man consumed by the "what ifs" of his daughter's death.

• Desiree del Valle as Ruth Balmaceda

- She is the Wife of Alvin, They share a "battle-hardened" love. They are partners in every sense—grieving together and fighting together.

• Wendy Valdez as Margie Dela Fuente

- Margie is the personal assistant to Donya Tomasa. She presents herself as a professional, loyal, and reliable employee, which allows her to move freely within the elite circles and religious settings of the town. Beneath her polished exterior, Margie is actually an Aswang. She serves as a mole, using her position to gather information and facilitate the dark agenda of her kind.

• Beverly Salviejo as Teacher

- Juan's Teacher, She always observes Juan's actions and movements inside the school.

• Arlene Tolibas as Audrey

- She is self-righteous, stern, and often acts as the "enforcer" for Donya Tomasa’s whims. She is one of the townspeople who is most vocal about her dislike for Juan, viewing him as a "son of the devil" and a menace to their peaceful community.

• Evelyn Santos as Beverley

- Often seen as the most talkative of the group. She is quick to spread rumors about Juan’s latest "misdeeds" and is deeply loyal to Donya Tomasa’s social hierarchy.

• Evelyn Sarza as Cassandra

- Another member of the parish group. Like Beverly, she represents the narrow-mindedness of the townspeople who refuse to see the good in Juan.

• Brenda Porcadilla as Daphnie

- Completes the trio/quartet of ladies. She is usually present during the church-related events where the group plots to get Juan in trouble or tries to impress the parish priest.

• Mel Kimura as Teacher Daisy

- Juan's Teacher, Who Assigned Buboy to become his Special Tutor for the Exam.

• Gerhard Acao as Steve

- Audrey's Husband and Lester's Father, he is the Toda/Tricycle Driver, Sometimes he with Juan.

• Nicky Castro as Lester

- Juan's Classmate and Audrey and Steve's Son, like his Mother, Lester hates Juan too.

• Johan Santos as Aswang
• Nico Antonio as Aswang
• Josh Morales as Aswang
• Yogo Singh as Clarence
• Matet de Leon as Irma
• Joross Gamboa as Jorge
• Gio Alvarez as Alberto
• Jose Sarasola as Aswang
• Nanding Josef as Mang Peping
• Charee Pineda as Atty. Esther Sandoval
• Christopher Roxas as Teroy
• Mike Lloren as Boyet
• Kyle Banzon as Estong
• Gerald Pesigan as Eloy
• Paolo Serrano as Jordan
• Jhiz Deocareza as Buboy
• Yayo Aguila as Bechay
• Niña Dolino as Marissa
• Jhong Hilario as Poldo
• Alex Medina as Jethro Sanchez
• Cara Eriguel as Danica
• Perla Bautista as Sunshine Domingo
• Chinggoy Alonzo as Manolo Domingo
• Pokwang as Sarah de Guzman
• Allan Paule as Mark de Guzman
• Tony Mabesa as Fr. Sarmiento
• Leo Rialp as Manuel "Manny" de Dios
• Boom Labrusca as Bobby
• Zeppi Borromeo as George
• Marvin Yap as Camping Teacher
• Quintin Alianza as Quintin