Nuclear receptor co-repressor 1
Protein found in humans
From Wikipedia, the free encyclopedia
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[5][6]
External IDsOMIM: 600849; MGI: 1349717; HomoloGene: 38166; GeneCards: NCOR1; OMA:NCOR1 - orthologs
NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.[5][7]
Loss of function of this protein significantly increases the strength and power of mouse muscles.[8]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.[9]
Interactions
Nuclear receptor co-repressor 1 has been shown to interact with:
- Androgen receptor,[10][11][12][13]
- CHD1,[14]
- Calcitriol receptor[15][16]
- GPS2,[17][18][19]
- Glucocorticoid receptor,[20][21]
- HDAC3,[17][18][19][22][23][24][25]
- HDAC4,[24][26]
- HDAC7A,[22]
- HDAC9,[27]
- HEY2,[28]
- Histone deacetylase 5,[17][26]
- MAP3K7IP2,[29]
- MECP2,[30]
- Peroxisome proliferator-activated receptor alpha,[31]
- Peroxisome proliferator-activated receptor gamma
- Promyelocytic leukemia protein,[32]
- RUNX1T1,[33][34]
- Retinoic acid receptor alpha,[31][35]
- Retinoic acid receptor gamma,[31]
- SAP30,[25][36]
- TBL1XR1,[17][18][19]
- TBL1X,[17][19][23][37] and
- ZBTB33.[18]
Further reading
- Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection". Semin. Cell Dev. Biol. 10 (2): 215–25. doi:10.1006/scdb.1999.0303. PMID 10441075.
- Downes M, Burke LJ, Bailey PJ, Muscat GE (1997). "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors". Nucleic Acids Res. 24 (22): 4379–86. doi:10.1093/nar/24.22.4379. PMC 146280. PMID 8948627.
- Tagami T, Madison LD, Nagaya T, Jameson JL (1997). "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone". Mol. Cell. Biol. 17 (5): 2642–8. doi:10.1128/mcb.17.5.2642. PMC 232114. PMID 9111334.
- Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996. PMID 9405624.
- Burke LJ, Downes M, Laudet V, Muscat GE (1998). "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha". Mol. Endocrinol. 12 (2): 248–62. doi:10.1210/mend.12.2.0061. PMID 9482666.
- Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
- Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes Dev. 12 (15): 2269–77. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
- Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell. 2 (1): 33–42. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189.
- Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
- Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. Bibcode:1999PNAS...96.2639O. doi:10.1073/pnas.96.6.2639. PMC 15821. PMID 10077563.
- Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.
- Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. Genet. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647. PMID 10441327.
- Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics. 59 (3): 339–41. doi:10.1006/geno.1998.5694. PMID 10444336.
- Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors". Nature. 402 (6757): 93–6. Bibcode:1999Natur.402...93H. doi:10.1038/47069. PMID 10573424. S2CID 4380362.
- Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. doi:10.1101/gad.14.1.45. PMC 316335. PMID 10640275.
- Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
- Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.