N'-Formylkynurenine
Chemical compound
From Wikipedia, the free encyclopedia
N′-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N′-formylkynurenine is catalyzed by heme dioxygenases.[1]
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| Names | |
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| Systematic IUPAC name
(2S)-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid | |
| Other names
N′-Formyl-L-kynurenine | |
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| MeSH | N'-formylkynurenine |
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| Properties | |
| C11H12N2O4 | |
| Molar mass | 236.227 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Biosynthesis
The enzyme indoleamine 2,3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway.[2]
Related enzymes performing a similar function are Indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase.[3][4]
Metabolism
In the main sequence of the kynurenine pathway, the formyl group is removed by the enzyme arylformamidase, giving the compound after which the pathway is named:[5]
Alternatively, the enzyme kynureninase can produce N-formylanthranilic acid and L-alanine:[6][7]
