Peptide alpha-N-acetyltransferase
Class of enzyme
From Wikipedia, the free encyclopedia
In enzymology, peptide α-N-acetyltransferase (EC 2.3.1.88) were enzymes that catalyzes the chemical reaction
- acetyl-CoA + peptide Nα-acetylpeptide + CoA
| peptide alpha-N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.88 | ||||||||
| CAS no. | 83452-29-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and peptide, whereas its two products are Nα-acetylpeptide and CoA. Since 2016, the different enzymes that used to be in this class are separated into NatA-NatF (EC 2.3.1.254 to EC 2.3.1.259).
These enzymes belong to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:peptide Nα-acetyltransferase. Other names in common use include beta-endorphin acetyltransferase, peptide acetyltransferase, protein N-terminal acetyltransferase, NAT, Nalpha-acetyltransferase, amino-terminal amino acid-acetylating enzyme, and acetyl-CoA:peptide alpha-N-acetyltransferase.
Structural studies
References
- Driessen HP, de Jong WW, Tesser GI, Bloemendal H (1985). "The mechanism of N-terminal acetylation of proteins". CRC Crit. Rev. Biochem. 18 (4): 281–325. doi:10.3109/10409238509086784. PMID 3902358.
- Glembotski CC (1982). "Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of beta-endorphin and alpha-melanotropin". J. Biol. Chem. 257 (17): 10501–9. doi:10.1016/S0021-9258(18)34046-8. PMID 6286657.
- O'Donohue TL (1983). "Identification of endorphin acetyltransferase in rat brain and pituitary gland". J. Biol. Chem. 258 (4): 2163–7. doi:10.1016/S0021-9258(18)32902-8. PMID 6296134.
- Tsunasawa S, Kamitani K, Narita K (February 1980). "Partial purification and properties of the amino-terminal amino acid-acetylating enzyme from hen's oviduct". J. Biochem. 87 (2): 645–50. doi:10.1093/oxfordjournals.jbchem.a132789. PMID 6244269.
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