Nucleobindin 1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.[5][6]
External IDsOMIM: 601323; MGI: 97388; HomoloGene: 4507; GeneCards: NUCB1; OMA:NUCB1 - orthologs
Structure
The human calnuc protein contains 461 amino acids and has a pI of 4.9.[7]
The protein contains the following regions and domains:
- Signal peptide[8]
- Leucine-zipper[8] The leucine-zipper of calnuc may be responsible for its dimerization.
- aa 347-389 – Nuclear localization signal
- 2 zinc binding sites[9] with high affinity (Kd = 20 nM)
- carboxypeptidase-like motifs : HFREXnH (aa 66) and HFTEXnH (aa 146)
- 2 EF-hands
- Potential anchor region[7]– 15-aa hydrophobic region at its COOH terminus that may be sufficient for membrane anchoring
