Nebraska Highway 50

N-50 begins at the Kansas border south of Du Bois. The highway extends into Kansas as K-63. It runs through farmland, passes through Du Bois, and meets N-8. The two highways overlap, first by going north and then by going west, into Pawnee City. In Pawnee City, the overlap with N-8 ends and a new one with N-65 begins. The two highways overlap going north out of Pawnee City and separate near Table Rock, Nebraska. Two miles north, N-50 briefly overlaps N-4 before going north again. Near Elk Creek, N-50 meets N-62. Further north, N-50 passes through Tecumseh and meets U.S. Highway 136. The highway continues due north from Tecumseh through Syracuse, passing by N-41 and N-128 between Tecumseh and Syracuse. In Syracuse, N-50 meets N-2.^[1][3]

N-50 continues due north from Syracuse, meeting US 34 near Avoca. Near Manley, N-50 meets N-1. It continues north and curves northeast before meeting N-66. N-50 and N-66 overlap until the southwestern edge of Louisville, where they separate, though signage on N-50 has "To N-66" signs in the Louisville area, due to a gap in that highway in Louisville. After passing through Louisville, N-50 immediately crosses the Platte River and then immediately meets N-31. N-50 then goes northeast briefly and turns north to go through Springfield, where the highway becomes divided. As the highway approaches Omaha, it meets N-370 and then Interstate 80. It then continues north into the Millard neighborhood of Omaha on 144th Street, then turns northeast onto Millard Avenue. After passing through Millard, N-50 ends by meeting US 275 and N-92.^[1][3]