Nesfatin-1
Neuropeptide produced in the hypothalamus of mammals
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Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage.[1] Increased nesfatin-1 in the hypothalamus contributes to diminished hunger, a 'sense of fullness', and a potential loss of body fat and weight.
A study of metabolic effects of nesfatin-1 in rats was done in which subjects administered nesfatin-1 ate less, used more stored fat and became more active. Nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of orexigenic neurons.[2] In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice.[3] Nesfatin-1 can cross the blood–brain barrier without saturation.[4]