Nicotinamidase
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In enzymology, a nicotinamidase (EC 3.5.1.19) is an enzyme that catalyzes the chemical reaction
- nicotinamide + H2O nicotinate + NH3
| nicotinamidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Nicotinamidase monomer, Saccharomyces cerevisiae | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.1.19 | ||||||||
| CAS no. | 9033-32-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are nicotinamide and H2O, whereas its two products are nicotinate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide amidohydrolase. Other names in common use include nicotinamide deaminase, nicotinamide amidase, and YNDase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
References
- Petrack B, Greengard P, Craston A, Sheppy F (1965). "Nicotinamide deamidase from mammalian liver". J. Biol. Chem. 240 (4): 1725–1730. doi:10.1016/S0021-9258(18)97496-X. PMID 14285515.
- Sarma DS, Rajalakshmi S, Sarma S (1964). "Studies on the enzymes involved in nicotinamide adenine dinucleotide metabolism in Aspergillus niger". Biochim. Biophys. Acta. 81 (2): 311–322. doi:10.1016/0926-6569(64)90047-1.
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