Nucleoside-triphosphatase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, a nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) is an enzyme that catalyzes the chemical reaction
- NTP + H2O NDP + phosphate
Thus, the two substrates of this enzyme are NTP and H2O, whereas its two products are NDP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and nucleoside 5-triphosphatase. This enzyme participates in purine metabolism and thiamine metabolism.
Structural studies
References
- Brightwell R, Tappel AL (1968). "Lysosomal acid pyrophosphatase and acid phosphatase". Arch. Biochem. Biophys. 124 (1): 333–43. doi:10.1016/0003-9861(68)90335-4. PMID 5661608.
- LEWIS M, WEISSMAN S (1965). "Properties of a soluble nucleoside triphosphatase activity in mammalian liver". Arch. Biochem. Biophys. 109 (3): 490–8. doi:10.1016/0003-9861(65)90393-0. PMID 14320490.
- Matsushita S, Raacke ID (1968). "Purification of nucleoside triphosphatases from pea seedling ribosomes". Biochim. Biophys. Acta. 166 (3): 707–10. doi:10.1016/0005-2787(68)90380-8. PMID 4301913.
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