ORG-25935

ORG-25935
Identifiers
	IUPAC name 2-([(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino)acetic acid;
CAS Number	1147011-84-4 ; HCl: 949588-40-3 ;
PubChem CID	11717074;
ChemSpider	9891795;
UNII	55L20667O4; HCl: H6MSM69SSM ;
CompTox Dashboard (EPA)	DTXSID401045253 ;
Chemical and physical data
Formula	C21H25NO3
Molar mass	339.435 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CN(C)C[C@@H]2[C@@H](c1c(cc(OC)cc1)CC2)c3ccccc3;
	InChI InChI=1S/C21H25NO3/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24)/t17-,21+/m1/s1; Key:UEBBYLJZCHTLEG-UTKZUKDTSA-N;

ORG-25935, also known as SCH-900435 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1. In animal tests it reduces alcohol consumption and has analgesic and anticonvulsant effects, but it has mainly been studied for its antipsychotic properties, and in human trials it was shown to effectively counteract the effects of the dissociative drug ketamine.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Quick facts Identifiers, CAS Number ...

Close

See also

Identifiers

IUPAC name 2-([(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino)acetic acid
CAS Number	1147011-84-4^Y HCl: 949588-40-3^Y
PubChem CID	11717074
ChemSpider	9891795
UNII	55L20667O4 HCl: H6MSM69SSM^Y
CompTox Dashboard (EPA)	DTXSID401045253
Chemical and physical data
Formula	C₂₁H₂₅NO₃
Molar mass	339.435 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)CN(C)C[C@@H]2[C@@H](c1c(cc(OC)cc1)CC2)c3ccccc3
InChI InChI=1S/C21H25NO3/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24)/t17-,21+/m1/s1 Key:UEBBYLJZCHTLEG-UTKZUKDTSA-N