ORG-37684

ORG-37684
Clinical data
Other names	ORG37684; ORG-37,684
Drug class	Serotonin 5-HT2 receptor agonist; Serotonin 5-HT2C receptor agonist; Serotonin 5-HT2A receptor agonist
ATC code	None;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine;
CAS Number	436083-07-7 ; 213007-95-5 (hydrochloride);
PubChem CID	9794656;
IUPHAR/BPS	171;
ChemSpider	7970423;
UNII	Y4D42A6EDS;
CompTox Dashboard (EPA)	DTXSID201029269 ;
Chemical and physical data
Formula	C14H19NO2
Molar mass	233.311 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1c(OC)ccc2c1CCC2)[C@H]3CCNC3;
	InChI InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1; Key:QDJAYXYEXHVXJV-NSHDSACASA-N;
	(verify)

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT₂ receptor family, including of the serotonin 5-HT_2C, 5-HT_2B, and 5-HT_2A receptors, in that order of potency.^[1]^[2]^[3] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.^[4] ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans.^[1] The drug was under development for the treatment of major depressive disorder in the 1990s and early 2000s, and reached the preclinical research stage, but development was discontinued and it was never marketed.^[5]^[6]