PADI3

Peptidyl arginine deiminase, type III, also known as PADI3, is a protein which in humans is encoded by the PADI3 gene.^[5][6]

AliasesPADI3, PAD3, PDI3, peptidyl arginine deiminase 3, UHS1

External IDsOMIM: 606755; MGI: 1338891; HomoloGene: 7882; GeneCards: PADI3; OMA:PADI3 - orthologs

Chr.Chromosome 1 (human)^[1]

End17,284,233 bp^[1]

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PADI3
Identifiers
Aliases	PADI3, PAD3, PDI3, peptidyl arginine deiminase 3, UHS1
External IDs	OMIM: 606755; MGI: 1338891; HomoloGene: 7882; GeneCards: PADI3; OMA:PADI3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 17,249,098 bp[1] End 17,284,233 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 72.5 cM Start 140,512,676 bp[2] End 140,537,959 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urinary bladder testicle olfactory zone of nasal mucosa vagina tonsil skin of abdomen gallbladder gonad prostate skin of leg Top expressed in lip hair follicle skin of back embryo granulocyte skin of abdomen morula transitional epithelium of urinary bladder epiblast Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity calcium ion binding identical protein binding protein-arginine deiminase activity Cellular component cytosol nucleus cytoplasm Biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51702 18601 Ensembl ENSG00000280549 ENSG00000142619 ENSMUSG00000025328 UniProt Q9ULW8 Q9Z184 RefSeq (mRNA) NM_016233 NM_011060 RefSeq (protein) NP_057317 NP_035190 Location (UCSC) Chr 1: 17.25 – 17.28 Mb Chr 4: 140.51 – 140.54 Mb PubMed search [3] [4]
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This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.^[5]