Serine/threonine-protein kinase N3

Serine/threonine-protein kinase N3 is a protein kinase C-related molecule which in humans is encoded by the PKN3 gene. It is thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K).^[5] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.^[6]

AliasesPKN3, UTDP4-1, protein kinase N3

External IDsOMIM: 610714; MGI: 2388285; GeneCards: PKN3

Chr.Chromosome 9 (human)^[1]

End128,720,916 bp^[1]

Quick facts PKN3, Identifiers ...

PKN3
Identifiers
Aliases	PKN3, UTDP4-1, protein kinase N3
External IDs	OMIM: 610714; MGI: 2388285; GeneCards: PKN3
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.13 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,702,503 bp[1] End 128,720,916 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,077,684 bp[2] End 30,091,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ventricular zone right lung upper lobe of left lung subcutaneous adipose tissue minor salivary glands left ventricle right hemisphere of cerebellum testicle left uterine tube Top expressed in otic vesicle yolk sac semi-lunar valve endothelial cell of lymphatic vessel aortic valve condyle esophagus renal corpuscle ascending aorta fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding kinase activity Cellular component cytoplasm perinuclear region of cytoplasm Golgi apparatus nucleus Biological process protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation epithelial cell migration phosphorylation signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 29941 263803 Ensembl ENSG00000160447 ENSMUSG00000026785 UniProt Q6P5Z2 Q8K045 RefSeq (mRNA) NM_013355 NM_001317926 NM_153805 RefSeq (protein) NP_001304855 NP_037487 NP_722500 Location (UCSC) Chr 9: 128.7 – 128.72 Mb Chr 2: 30.08 – 30.09 Mb PubMed search [3] [4]
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PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.