PPP3CA

PPP3CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Identifiers
Aliases	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91
External IDs	OMIM: 114105; MGI: 107164; HomoloGene: 55497; GeneCards: PPP3CA; OMA:PPP3CA - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	101,348,278 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	136,643,488 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; Region I of hippocampus proper; ; postcentral gyrus; ; Brodmann area 46; ; entorhinal cortex; ; orbitofrontal cortex; ; external globus pallidus; ; pons;
	Top expressed in
	olfactory tubercle; ; hippocampus proper; ; lateral septal nucleus; ; globus pallidus; ; nucleus accumbens; ; anterior amygdaloid area; ; lobe of cerebellum; ; subiculum; ; Region I of hippocampus proper; ; prefrontal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphoprotein phosphatase activity; protein dimerization activity; protein serine/threonine phosphatase activity; metal ion binding; calmodulin binding; protein binding; protein heterodimerization activity; enzyme binding; calcium-dependent protein serine/threonine phosphatase activity; hydrolase activity; cyclosporin A binding; calmodulin-dependent protein phosphatase activity;
Cellular component	membrane; plasma membrane; calcineurin complex; nucleoplasm; Z discdkac; mitochondrion; sarcolemma; nucleus; cytosol; cytoplasm; cytoplasmic side of plasma membrane; dendritic spine; slit diaphragm; cell projection; synapse; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	multicellular organismal response to stress; negative regulation of insulin secretion; protein import into nucleus; transition between fast and slow fiber; negative regulation of chromatin binding; response to amphetamine; modulation of chemical synaptic transmission; positive regulation of DNA-binding transcription factor activity; response to calcium ion; Fc-epsilon receptor signaling pathway; cardiac muscle hypertrophy in response to stress; negative regulation of dendrite morphogenesis; skeletal muscle fiber development; positive regulation of cardiac muscle hypertrophy in response to stress; excitatory postsynaptic potential; T cell activation; cellular response to glucose stimulus; calcium ion transport; calcium-mediated signaling; dephosphorylation; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway, calcium modulating pathway; positive regulation of cardiac muscle hypertrophy; positive regulation of gene expression; negative regulation of gene expression; negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of connective tissue replacement; positive regulation of endocytosis; G1/S transition of mitotic cell cycle; protein dephosphorylation; calcineurin-NFAT signaling cascade; positive regulation of calcineurin-NFAT signaling cascade; brain development; positive regulation of cell migration; skeletal muscle tissue regeneration; positive regulation of cell adhesion; calcineurin-mediated signaling; postsynaptic modulation of chemical synaptic transmission; ageing; peptidyl-serine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5530
	19055
	ENSG00000138814
	ENSMUSG00000028161
	Q08209
	P63328
	NM_001130692; NM_000944; NM_001130691
	NM_001293622; NM_008913
	NP_000935; NP_001124163; NP_001124164
	NP_001280551; NP_032939
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.^[5]^[6]