Trypsin-2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Trypsin-2 (also called serine protease 2) is an enzyme that in humans is encoded by the PRSS2 gene.[5] Trypsin-2 is a digestive enzyme which functions to break down proteins as a protease.[6] Like other trypsins it is secreted in its inactive, trypsinogen form by the acinar cells of the pancreas into the small intestines as part of pancreatic juice.[6] It is distinctive in its potential ability to degrade type II collagen, which may be connected to rheumatoid arthritis.[5]
| PRSS2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PRSS2, TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601564; MGI: 102759; GeneCards: PRSS2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].
