Phosphoribosyl-AMP cyclohydrolase
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In enzymology, a phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) is an enzyme that catalyzes the chemical reaction
- 1-(5-phosphoribosyl)-AMP + H2O 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
| phosphoribosyl-AMP cyclohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
phosphoribosyl-AMP cyclohydrolase dimer, Methanobacterium | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.4.19 | ||||||||
| CAS no. | 37289-22-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are [[1-(5-phosphoribosyl)-5-[(5-]] and [[phosphoribosylamino)methylideneamino]imidazole-4-carboxamide]].
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
Structural studies
References
- Minson AC, Creaser EH (1969). "Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa". Biochem. J. 114 (1): 49â56. doi:10.1042/bj1140049. PMC 1184794. PMID 4309307.
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