Piperylone
Chemical compound
From Wikipedia, the free encyclopedia
Piperylone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties.[1]
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| ECHA InfoCard | 100.017.990 |
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| Formula | C17H23N3O |
| Molar mass | 285.391 g·mol−1 |
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Synthesis
Hydrazone formation of 1-methyl-4-piperidone (1) with benzohydrazide (2) gives (3). Catalytic hydrogenation using Adams' catalyst gives the substituted hydrazine (6) after acid-catalyzed hydrolysis to remove the benzoyl group and neutralization. The pyrazolone ring is formed in a condensation reaction with ethyl 2-benzoylbutanoate (7), yielding piperylone.[2][3][4]
