Lipoblast
Precursor cell for an adipocyte (fat cell)
From Wikipedia, the free encyclopedia
A lipoblast is a precursor cell for an adipocyte.[1] Alternate terms include adipoblast[2] and preadipocyte.[3] Early stages are almost indistinguishable from fibroblasts.[4]
Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma
Histopathology of liposarcoma, H&E stain, with the main features:[5]
- Spindle cells with enlarged, hyperchromatic nuclei.
- Apparently univacuolated adipocytes (may look normal).
- Lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma.
Lipid-laden histiocytes may mimic lipoblasts, but have lightly eosinophilic cytoplasm and a small normochromatic nuclei which are not hollowed out from the lipid vacuoles.[6]
Liposarcoma
Lipoblasts are seen in liposarcoma[7] and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.
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