EZS-8

EZS-8
Clinical data
Other names	3-(2-Aminoethyl)quinazoline-2,4-dione
Drug class	Serotonin 5-HT2A receptor partial agonist
ATC code	None;
Identifiers
	IUPAC name 3-(2-aminoethyl)-1H-quinazoline-2,4-dione;
CAS Number	144734-40-7;
PubChem CID	10035843;
ChemSpider	8211408;
ChEMBL	ChEMBL144442;
Chemical and physical data
Formula	C10H11N3O2
Molar mass	205.217 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCN;
	InChI InChI=1S/C10H11N3O2/c11-5-6-13-9(14)7-3-1-2-4-8(7)12-10(13)15/h1-4H,5-6,11H2,(H,12,15); Key:NTAUXYQQSCPGHT-UHFFFAOYSA-N;

EZS-8, also known as 3-(2-aminoethyl)quinazoline-2,4-dione, is a very-low-potency serotonin 5-HT_2A receptor partial agonist related to ketanserin.^[1]^[2]^[3]^[4] It has about 0.15% of the potency (EC₅₀Tooltip half-maximal effective concentration = 66,000 nM) and 46% of the efficacy (E_maxTooltip maximal efficacy) of serotonin as a serotonin 5-HT_2A receptor agonist in vitro.^[1]^[2]^[3]^[4] The N-(2-methoxy)benzyl analogue of EZS-8, RH-34, has 250-fold greater potency as a serotonin 5-HT_2A receptor agonist in comparison.^[2]^[3]^[4] EZS-8 was first described in the scientific literature by 1999.^[1] N-Benzyl derivatives of EZS-8 like RH-34 had been described as early as 1996 or 1998.^[5]^[6]