All-trans-retinol 13,14-reductase
Class of enzymes
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In enzymology, all-trans-retinol 13,14-reductase (EC 1.3.99.23) is an enzyme, encoded by the RETSAT gene,[1][2] that catalyzes the chemical reaction
Aliases(13,14)-all-trans-retinol saturaseRetSatall-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductaseall-trans-retinol:all-trans-13,14-dihydroretinol saturaseretinol saturase
External IDsGeneCards: ; OMA:- orthologs
| All-trans-retinol 13,14-reductase | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | (13,14)-all-trans-retinol saturaseRetSatall-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductaseall-trans-retinol:all-trans-13,14-dihydroretinol saturaseretinol saturase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: ; OMA:- orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| all-trans-retinol 13,14-reductase | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.3.99.23 | ||||||||
| CAS no. | 418767-56-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme acts on retinol (vitamin A) to reduce it to 13,14-dihydroretinol. Its is not known to be able to catalyze reaction in the opposite direction.[3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase. Other names in common use include retinol saturase, RetSat, (13,14)-all-trans-retinol saturase, and all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
The gene has also been called PPAR-alpha-regulated and starvation-induced gene protein.[4]
