60S ribosomal protein L18

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.^[5][6]

AliasesRPL18, L18, ribosomal protein L18, DBA18

External IDsOMIM: 604179; MGI: 98003; GeneCards: RPL18

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 19 (human)^[1]

Quick facts RPL18, Identifiers ...

RPL18
Identifiers
Aliases	RPL18, L18, ribosomal protein L18, DBA18
External IDs	OMIM: 604179; MGI: 98003; GeneCards: RPL18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,615,328 bp[1] End 48,619,184 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,364,881 bp[2] End 45,370,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple human penis skin of thigh skin of hip urethra right uterine tube pylorus vulva left ovary skin of arm Top expressed in epiblast urinary bladder embryo bone marrow adrenal gland yolk sac embryo ventricular zone lip morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding structural constituent of ribosome Cellular component ribosome membrane focal adhesion intracellular anatomical structure nucleolus cytosolic large ribosomal subunit nucleus cytoplasm endoplasmic reticulum cytosol rough endoplasmic reticulum polysomal ribosome Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6141 19899 Ensembl ENSG00000063177 ENSMUSG00000059070 UniProt Q07020 P35980 RefSeq (mRNA) NM_000979 NM_001270490 NM_009077 RefSeq (protein) NP_000970 NP_001257419 NP_033103 Location (UCSC) Chr 19: 48.62 – 48.62 Mb Chr 7: 45.36 – 45.37 Mb PubMed search [3] [4]
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]