60S ribosomal protein L8

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.^[5][6][7]

AliasesRPL8, L8, ribosomal protein L8

External IDsOMIM: 604177; MGI: 1350927; GeneCards: RPL8

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 8 (human)^[1]

Quick facts RPL8, Identifiers ...

RPL8
Identifiers
Aliases	RPL8, L8, ribosomal protein L8
External IDs	OMIM: 604177; MGI: 1350927; GeneCards: RPL8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CCM, 4CCN, 4CCO, 4UG0, 4V6X, 5AJ0, 4D67, 3J7Q, 4Y3O, 4UJC, 3J7R, 4D5Y, 4UJE, 4UJD, 3J7P, 3J7O, 3J92, 4V5Z
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,789,765 bp[1] End 144,792,587 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,788,278 bp[2] End 76,790,514 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ovary left ovary trachea right ovary thymus mucosa of transverse colon ventricular zone pituitary gland skin of leg Top expressed in primitive streak hair follicle abdominal wall efferent ductule transitional epithelium of urinary bladder medial ganglionic eminence endothelial cell of lymphatic vessel mandibular prominence maxillary prominence condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding structural constituent of ribosome RNA binding 5.8S rRNA binding Cellular component cytosol ribosome membrane focal adhesion large ribosomal subunit intracellular anatomical structure cytoplasm cytosolic large ribosomal subunit postsynaptic density polysomal ribosome synapse postsynapse Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6132 26961 Ensembl ENSG00000161016 ENSMUSG00000003970 UniProt P62917 P62918 RefSeq (mRNA) NM_000973 NM_033301 NM_001317771 NM_001317782 NM_012053 RefSeq (protein) NP_000964 NP_001304700 NP_001304711 NP_150644 NP_036183 Location (UCSC) Chr 8: 144.79 – 144.79 Mb Chr 15: 76.79 – 76.79 Mb PubMed search [3] [4]
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]