Fowler always kept up an interest in science, without producing any notable original work. While a student in Edinburgh, after his return from Paris, he was fascinated by the recent discoveries of Galvani on the form of electricity called by his name, and made numerous experiments on the subject, which were published in a small volume entitled 'Experiments and Observations on the Influence lately discovered by M. Galvani, and commonly called Animal Electricity,’ 8vo, Edinburgh, 1793. It contains, also, observations on the action of opium on nerves and muscles. Many years after Fowler published two small books on the psychology of persons in whom the senses are defective, viz. 'Observations on the Mental State of the Blind and Deaf and Dumb,’ 12mo, Salisbury, 1843; 2nd edit. 1860; and 'The Physiological Processes of Thinking, especially in Persons whose Organs of Sense are Defective,’ 12mo, Salisbury, 1849; 2nd edit. 1852. These works show some reading, and contain interesting observations, but are wanting in lucidity and in philosophical method. He also wrote 'On Literary and Scientific Pursuits as conducive to Longevity,’ Salisbury, 1855, 12mo. Fowler appears to have written nothing on purely medical subjects, but contributed memoirs to the 'Proceedings of the British Association,’ some of which were published separately.
In 1860 he founded the Salisbury and South Wiltshire Museum in St Ann's Street, Salisbury.