RIT2

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.^[5][6][7]

AliasesRIT2, RIBA, RIN, ROC2, Ras like without CAAX 2

External IDsOMIM: 609592; MGI: 108054; HomoloGene: 2198; GeneCards: RIT2; OMA:RIT2 - orthologs

Chr.Chromosome 18 (human)^[1]

End43,115,691 bp^[1]

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RIT2
Identifiers
Aliases	RIT2, RIBA, RIN, ROC2, Ras like without CAAX 2
External IDs	OMIM: 609592; MGI: 108054; HomoloGene: 2198; GeneCards: RIT2; OMA:RIT2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 42,743,227 bp[1] End 43,115,691 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 31,106,542 bp[2] End 31,450,343 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis endothelial cell Brodmann area 9 prefrontal cortex nucleus accumbens hypothalamus right frontal lobe Top expressed in ventral tegmental area dorsal tegmental nucleus dorsomedial hypothalamic nucleus medial vestibular nucleus habenula suprachiasmatic nucleus central gray substance of midbrain paraventricular nucleus of hypothalamus arcuate nucleus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding identical protein binding GTP binding protein binding semaphorin receptor binding chromatin binding GTPase activity GDP binding Cellular component membrane membrane raft plasma membrane nucleus neuron projection cytoplasm cell body dendritic tree Biological process chemical synaptic transmission signal transduction MAPK cascade maintenance of protein location in cell regulation of endocytosis intracellular signal transduction regulation of protein phosphorylation Ras protein signal transduction positive regulation of neuron projection development negative regulation of neuron projection development regulation of Cdc42 protein signal transduction positive regulation of MAPK cascade positive regulation of transcription by RNA polymerase II regulation of calcium-mediated signaling small GTPase mediated signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6014 19762 Ensembl ENSG00000152214 ENSMUSG00000057455 UniProt Q99578 P70425 RefSeq (mRNA) NM_002930 NM_001272077 NM_009065 RefSeq (protein) NP_001259006 NP_002921 NP_033091 Location (UCSC) Chr 18: 42.74 – 43.12 Mb Chr 18: 31.11 – 31.45 Mb PubMed search [3] [4]
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RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]^[7]

RIT2 has been associated with Parkinson's disease in two large genetic studies.^[8][9] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.^[10]